A focused product opportunity in metabolic oncology.
Published cancer biology, a defined lead program, and milestones designed to establish product differentiation.
At a glance
One lead program. A defined next stage.
NanomediGene is developing a formulation of a dual ACC1/ACC2 inhibitor for breast cancer. Initial formulation work and an animal pilot are complete. Findings guide follow-up studies of formulation, dose, and schedule.
Develop a differentiated ACC-inhibitor formulation.
Our lead program pairs a metabolic mechanism—ACC1/ACC2 inhibition—with a formulation strategy intended to improve therapeutic index. The development question is whether changing delivery can preserve antitumor activity while improving tolerability relative to the unformulated inhibitor.
We are developing a specific therapeutic formulation. Reproducible manufacturing and comparative studies of activity, exposure, and tolerability will determine its product profile. TROP2-directed targeting is planned and requires validation.
Published scientific rationaleMarczyk et al. (2022) and Shan et al. (2026; senior author Lajos Pusztai) inform the ACC program.
Initial formulation and pilot work completedCompleted in-house formulation work and an initial animal pilot inform follow-up studies of formulation, dose, and schedule. Comparative studies of antitumor activity, exposure, and tolerability are needed to establish therapeutic index.
External recognitionBest Biotech in the E-Poster category at the 2026 Yale Innovation Summit.
Selected for NCI STEP Stage 2NanomediGene completed Stage 1 of the NCI SBIR/STTR Training and Entrepreneurship Program and was one of ten companies selected to advance to Stage 2. About NCI STEP.
Partnering
Build the evidence. Advance toward partnering.
Our goal is to advance the lead formulation toward clinical readiness and pursue licensing or co-development with oncology partners.
The partnering path will depend on comparative product evidence, manufacturing readiness, financing, and appropriate intellectual-property and development rights.
Contact us for a program briefing covering pilot findings, development requirements, and relevant intellectual-property and licensing information. Detailed study data are available for follow-up discussions.
This website is provided for informational purposes only and does not constitute an offer to sell, or a solicitation of an offer to buy, any securities. Any securities offering would be made through appropriate offering documents and in accordance with applicable law. Nothing here is investment, legal, or tax advice.
Forward-looking statements
Statements about planned studies, targeting, therapeutic index, manufacturing, financing, partnerships, regulatory development, and future milestones reflect current expectations and involve risks and uncertainties. Actual results and timing may differ materially because of research outcomes, safety or efficacy findings, manufacturing challenges, intellectual-property or licensing matters, financing availability, and regulatory requirements. Preclinical findings do not establish clinical benefit. NMG’s investigational formulations have not been shown to be safe or effective in humans. Statements speak as of their publication date; we undertake no obligation to update them except as required by law.